2021 American Athletic Conference Leaders Passes Defended - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Cincinnati | 13 | 16 | 47 | 63 | 4.85 |
| 2 | UCF | 12 | 10 | 51 | 61 | 5.08 |
| 3 | Houston | 13 | 14 | 41 | 55 | 4.23 |
| 4 | Memphis | 11 | 8 | 46 | 54 | 4.91 |
| 5 | East Carolina | 11 | 14 | 36 | 50 | 4.55 |
| 6 | Tulsa | 12 | 11 | 38 | 49 | 4.08 |
| 7 | SMU | 11 | 7 | 34 | 41 | 3.73 |
| 8 | Tulane | 11 | 8 | 29 | 37 | 3.36 |
| 9 | Temple | 11 | 5 | 31 | 36 | 3.27 |
| 10 | Navy | 12 | 7 | 27 | 34 | 2.83 |
| 11 | South Florida | 11 | 10 | 21 | 31 | 2.82 |