2021 American Athletic Conference Leaders Passes Defended - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Cincinnati | 7 | 12 | 29 | 41 | 5.86 |
| 2 | Houston | 9 | 11 | 28 | 39 | 4.33 |
| 3 | Tulsa | 7 | 6 | 21 | 27 | 3.86 |
| 4 | Memphis | 5 | 3 | 21 | 24 | 4.80 |
| 5 | UCF | 6 | 2 | 21 | 23 | 3.83 |
| 6 | Tulane | 6 | 2 | 20 | 22 | 3.67 |
| 7 | Temple | 6 | 3 | 18 | 21 | 3.50 |
| 8 | SMU | 6 | 2 | 15 | 17 | 2.83 |
| 9 | East Carolina | 6 | 5 | 11 | 16 | 2.67 |
| 10 | Navy | 6 | 2 | 13 | 15 | 2.50 |
| 11 | South Florida | 6 | 3 | 10 | 13 | 2.17 |