2021 American Athletic Conference Leaders Passes Defended - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Cincinnati | 3 | 4 | 12 | 16 | 5.33 |
| 2 | Tulane | 4 | 3 | 12 | 15 | 3.75 |
| 3 | Tulsa | 4 | 4 | 6 | 10 | 2.50 |
| 4 | Temple | 2 | 0 | 8 | 8 | 4.00 |
| 5 | East Carolina | 2 | 2 | 5 | 7 | 3.50 |
| 5 | SMU | 2 | 0 | 7 | 7 | 3.50 |
| 5 | South Florida | 4 | 2 | 5 | 7 | 1.75 |
| 8 | Navy | 3 | 1 | 5 | 6 | 2.00 |
| 9 | Memphis | 1 | 2 | 3 | 5 | 5.00 |
| 10 | UCF | 1 | 0 | 3 | 3 | 3.00 |
| 11 | Houston | 1 | 0 | 2 | 2 | 2.00 |