2021 American Athletic Conference Leaders Passes Defended - Games in August/September Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Memphis | 4 | 1 | 25 | 26 | 6.50 |
| 2 | East Carolina | 4 | 5 | 20 | 25 | 6.25 |
| 3 | Cincinnati | 3 | 6 | 14 | 20 | 6.67 |
| 4 | SMU | 4 | 6 | 13 | 19 | 4.75 |
| 5 | UCF | 3 | 3 | 14 | 17 | 5.67 |
| 6 | Tulsa | 4 | 3 | 12 | 15 | 3.75 |
| 7 | Tulane | 4 | 5 | 7 | 12 | 3.00 |
| 7 | South Florida | 4 | 3 | 9 | 12 | 3.00 |
| 9 | Navy | 3 | 2 | 8 | 10 | 3.33 |
| 9 | Houston | 4 | 3 | 7 | 10 | 2.50 |
| 9 | Temple | 4 | 3 | 7 | 10 | 2.50 |