2021 American Athletic Conference Leaders Passes Defended - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | UCF | 5 | 6 | 28 | 34 | 6.80 |
| 2 | Cincinnati | 5 | 9 | 24 | 33 | 6.60 |
| 3 | Memphis | 4 | 1 | 25 | 26 | 6.50 |
| 4 | East Carolina | 4 | 5 | 20 | 25 | 6.25 |
| 5 | SMU | 4 | 6 | 13 | 19 | 4.75 |
| 5 | Tulsa | 5 | 4 | 15 | 19 | 3.80 |
| 5 | Houston | 5 | 3 | 16 | 19 | 3.80 |
| 8 | Navy | 4 | 2 | 12 | 14 | 3.50 |
| 9 | Tulane | 4 | 5 | 7 | 12 | 3.00 |
| 9 | South Florida | 4 | 3 | 9 | 12 | 3.00 |
| 11 | Temple | 4 | 3 | 7 | 10 | 2.50 |