2021 American Athletic Conference Leaders Rushing Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 8 | 330 | 1279 | 3.88 | 6 | 41.25 | 159.88 |
| 2 | Houston | 5 | 143 | 518 | 3.62 | 7 | 28.60 | 103.60 |
| 3 | SMU | 4 | 143 | 581 | 4.06 | 8 | 35.75 | 145.25 |
| 4 | East Carolina | 6 | 214 | 934 | 4.36 | 11 | 35.67 | 155.67 |
| 4 | UCF | 4 | 143 | 738 | 5.16 | 11 | 35.75 | 184.50 |
| 6 | Tulsa | 5 | 187 | 826 | 4.42 | 12 | 37.40 | 165.20 |
| 7 | Memphis | 7 | 287 | 1147 | 4.00 | 15 | 41.00 | 163.86 |
| 7 | Temple | 5 | 204 | 1157 | 5.67 | 15 | 40.80 | 231.40 |
| 9 | Navy | 10 | 328 | 1288 | 3.93 | 20 | 32.80 | 128.80 |
| 9 | South Florida | 8 | 307 | 1754 | 5.71 | 20 | 38.38 | 219.25 |
| 11 | Tulane | 9 | 377 | 1678 | 4.45 | 22 | 41.89 | 186.44 |