2021 American Athletic Conference Leaders Rushing Defense - From Opponent's 40 to Own 40 Yard Line through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 14 | 111 | 450 | 4.05 | 4 | 44 | 26 | 13 | 7 |
| 1 | Navy | 12 | 97 | 450 | 4.64 | 2 | 56 | 25 | 16 | 3 |
| 3 | Tulane | 12 | 129 | 463 | 3.59 | 0 | 37 | 35 | 16 | 5 |
| 4 | SMU | 12 | 108 | 475 | 4.40 | 2 | 58 | 26 | 16 | 4 |
| 5 | East Carolina | 11 | 90 | 519 | 5.77 | 1 | 49 | 28 | 15 | 8 |
| 6 | Memphis | 12 | 122 | 542 | 4.44 | 1 | 44 | 33 | 19 | 4 |
| 7 | Tulsa | 13 | 120 | 554 | 4.62 | 2 | 52 | 25 | 17 | 6 |
| 8 | South Florida | 12 | 126 | 670 | 5.32 | 2 | 55 | 35 | 21 | 5 |
| 9 | UCF | 13 | 129 | 673 | 5.22 | 1 | 56 | 36 | 20 | 5 |
| 10 | Cincinnati | 14 | 164 | 717 | 4.37 | 1 | 47 | 45 | 24 | 3 |
| 11 | Temple | 12 | 140 | 1036 | 7.40 | 2 | 58 | 51 | 37 | 14 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||