2021 American Athletic Conference Leaders Rushing Defense - When Winning By 15+ Pts through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Temple | 2 | 25 | 67 | 2.68 | 0 | 13 | 4 | 3 | 0 |
| 2 | Navy | 1 | 12 | 71 | 5.92 | 1 | 24 | 3 | 3 | 1 |
| 3 | Tulane | 2 | 52 | 106 | 2.04 | 1 | 25 | 11 | 4 | 2 |
| 4 | Tulsa | 4 | 32 | 124 | 3.88 | 1 | 19 | 5 | 3 | 0 |
| 5 | South Florida | 2 | 21 | 143 | 6.81 | 1 | 40 | 5 | 5 | 2 |
| 6 | UCF | 4 | 63 | 214 | 3.40 | 2 | 45 | 8 | 5 | 2 |
| 7 | East Carolina | 4 | 50 | 226 | 4.52 | 4 | 40 | 12 | 7 | 3 |
| 8 | Memphis | 6 | 76 | 243 | 3.20 | 2 | 15 | 18 | 7 | 0 |
| 9 | Houston | 8 | 112 | 267 | 2.38 | 1 | 21 | 16 | 8 | 3 |
| 10 | SMU | 7 | 112 | 528 | 4.71 | 5 | 58 | 23 | 19 | 5 |
| 11 | Cincinnati | 12 | 226 | 822 | 3.64 | 7 | 51 | 48 | 26 | 5 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||