2021 American Athletic Conference Leaders Rushing Defense - On 2nd Down through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 14 | 136 | 438 | 3.22 | 5 | 44 | 32 | 16 | 3 |
| 2 | Navy | 12 | 126 | 524 | 4.16 | 7 | 56 | 34 | 21 | 3 |
| 3 | Tulane | 12 | 151 | 602 | 3.99 | 11 | 62 | 38 | 17 | 7 |
| 4 | SMU | 12 | 143 | 650 | 4.55 | 3 | 58 | 30 | 21 | 8 |
| 5 | South Florida | 12 | 128 | 678 | 5.30 | 7 | 69 | 45 | 23 | 6 |
| 6 | Cincinnati | 14 | 198 | 729 | 3.68 | 6 | 51 | 49 | 21 | 2 |
| 7 | UCF | 13 | 159 | 732 | 4.60 | 6 | 45 | 38 | 25 | 6 |
| 8 | East Carolina | 12 | 135 | 763 | 5.65 | 9 | 49 | 44 | 24 | 10 |
| 9 | Tulsa | 13 | 165 | 773 | 4.68 | 5 | 64 | 32 | 22 | 6 |
| 10 | Memphis | 12 | 158 | 774 | 4.90 | 6 | 38 | 46 | 23 | 4 |
| 11 | Temple | 12 | 193 | 944 | 4.89 | 15 | 47 | 64 | 37 | 6 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||