2021 American Athletic Conference Leaders Rushing Defense - On 1st Down through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | SMU | 12 | 197 | 634 | 3.22 | 7 | 31 | 14 | 14 | 4 |
| 2 | Tulsa | 13 | 225 | 830 | 3.69 | 11 | 54 | 24 | 25 | 6 |
| 3 | Navy | 12 | 184 | 853 | 4.64 | 15 | 78 | 21 | 23 | 6 |
| 4 | Memphis | 12 | 228 | 883 | 3.87 | 11 | 57 | 25 | 26 | 7 |
| 5 | Houston | 14 | 214 | 911 | 4.26 | 6 | 79 | 20 | 21 | 9 |
| 6 | Tulane | 12 | 236 | 986 | 4.18 | 8 | 68 | 31 | 31 | 7 |
| 7 | Cincinnati | 14 | 268 | 1023 | 3.82 | 7 | 33 | 29 | 30 | 3 |
| 8 | East Carolina | 12 | 195 | 1027 | 5.27 | 7 | 90 | 29 | 30 | 11 |
| 9 | UCF | 13 | 223 | 1052 | 4.72 | 12 | 79 | 34 | 34 | 10 |
| 10 | Temple | 12 | 261 | 1239 | 4.75 | 14 | 75 | 29 | 30 | 10 |
| 11 | South Florida | 12 | 230 | 1341 | 5.83 | 15 | 97 | 42 | 43 | 11 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||