2021 American Athletic Conference Leaders Rushing Defense - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulane | 2 | 74 | 179 | 2.42 | 3 | 37.00 | 89.50 |
| 2 | Navy | 2 | 62 | 284 | 4.58 | 5 | 31.00 | 142.00 |
| 3 | South Florida | 3 | 93 | 601 | 6.46 | 7 | 31.00 | 200.33 |
| 4 | Cincinnati | 5 | 216 | 716 | 3.31 | 7 | 43.20 | 143.20 |
| 5 | Memphis | 4 | 174 | 758 | 4.36 | 6 | 43.50 | 189.50 |
| 6 | East Carolina | 5 | 159 | 875 | 5.50 | 7 | 31.80 | 175.00 |
| 7 | Tulsa | 7 | 246 | 943 | 3.83 | 7 | 35.14 | 134.71 |
| 8 | Houston | 8 | 268 | 944 | 3.52 | 6 | 33.50 | 118.00 |
| 9 | SMU | 7 | 267 | 951 | 3.56 | 7 | 38.14 | 135.86 |
| 10 | UCF | 8 | 322 | 1308 | 4.06 | 13 | 40.25 | 163.50 |
| 11 | Temple | 6 | 303 | 1366 | 4.51 | 17 | 50.50 | 227.67 |