2021 American Athletic Conference Leaders Rushing Defense - Games Lost Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | SMU | 4 | 152 | 497 | 3.27 | 6 | 38.00 | 124.25 |
| 2 | Navy | 8 | 270 | 1087 | 4.03 | 20 | 33.75 | 135.88 |
| 3 | East Carolina | 5 | 178 | 720 | 4.04 | 7 | 35.60 | 144.00 |
| 4 | Tulane | 10 | 411 | 1734 | 4.22 | 23 | 41.10 | 173.40 |
| 5 | Houston | 2 | 56 | 355 | 6.34 | 5 | 28.00 | 177.50 |
| 6 | Tulsa | 6 | 257 | 1109 | 4.32 | 11 | 42.83 | 184.83 |
| 7 | Memphis | 6 | 275 | 1194 | 4.34 | 14 | 45.83 | 199.00 |
| 8 | South Florida | 10 | 386 | 2307 | 5.98 | 26 | 38.60 | 230.70 |
| 9 | Temple | 9 | 426 | 2195 | 5.15 | 30 | 47.33 | 243.89 |
| 10 | UCF | 4 | 191 | 1116 | 5.84 | 16 | 47.75 | 279.00 |
| 11 | Cincinnati | 1 | 47 | 301 | 6.40 | 0 | 47.00 | 301.00 |