2021 American Athletic Conference Leaders Rushing Defense - Games in October Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 4 | 125 | 257 | 2.06 | 3 | 31.25 | 64.25 |
| 2 | Navy | 5 | 143 | 652 | 4.56 | 7 | 28.60 | 130.40 |
| 3 | SMU | 4 | 167 | 561 | 3.36 | 4 | 41.75 | 140.25 |
| 4 | Cincinnati | 5 | 206 | 702 | 3.41 | 6 | 41.20 | 140.40 |
| 5 | East Carolina | 4 | 128 | 575 | 4.49 | 7 | 32.00 | 143.75 |
| 6 | Tulsa | 4 | 166 | 710 | 4.28 | 9 | 41.50 | 177.50 |
| 7 | South Florida | 4 | 154 | 730 | 4.74 | 6 | 38.50 | 182.50 |
| 8 | Tulane | 4 | 155 | 755 | 4.87 | 11 | 38.75 | 188.75 |
| 9 | Memphis | 4 | 185 | 805 | 4.35 | 6 | 46.25 | 201.25 |
| 10 | UCF | 5 | 221 | 1032 | 4.67 | 10 | 44.20 | 206.40 |
| 11 | Temple | 4 | 187 | 1056 | 5.65 | 10 | 46.75 | 264.00 |