2021 American Athletic Conference Leaders Rushing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Memphis | 1 | 16 | 49 | 3.06 | 1 | 16.00 | 49.00 |
| 2 | East Carolina | 1 | 39 | 99 | 2.54 | 0 | 39.00 | 99.00 |
| 3 | Houston | 2 | 57 | 270 | 4.74 | 3 | 28.50 | 135.00 |
| 4 | SMU | 1 | 30 | 170 | 5.67 | 1 | 30.00 | 170.00 |
| 5 | UCF | 2 | 67 | 396 | 5.91 | 5 | 33.50 | 198.00 |
| 6 | Temple | 2 | 89 | 399 | 4.48 | 9 | 44.50 | 199.50 |
| 7 | Cincinnati | 2 | 84 | 453 | 5.39 | 1 | 42.00 | 226.50 |
| 8 | Tulsa | 2 | 84 | 459 | 5.46 | 4 | 42.00 | 229.50 |
| 9 | Tulane | 2 | 96 | 488 | 5.08 | 9 | 48.00 | 244.00 |
| 10 | South Florida | 2 | 84 | 656 | 7.81 | 7 | 42.00 | 328.00 |